Substrate: eIF4E-binding protein 1 (Eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I))
Seq-ID: Q13541 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19057   IF4E_HUMAN
MINT-64139   ERG19_HUMAN
MINT-6549354   RPTOR_HUMAN
MINT-7021879   HS90B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytosol TOR signaling cascade,
positive regulation of mitotic cell cycle,
G1/S transition of mitotic cell cycle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 8    MSGGSSCSQTPSRAIPAT ATM 10713094
LTP
0.17
 MOD_PIKK_1
 - eIF_4EBP
0.79
 - medium
T 36 GVQLPPGDYSTTPGGTLFSTT - 18220336
HTP
0.98
 - eIF_4EBP
0.81
 - medium
T 36 GVQLPPGDYSTTPGGTLFSTT - 18669648
HTP
0.98
 - eIF_4EBP
0.81
 - medium
T 37 VQLPPGDYSTTPGGTLFSTTP mTOR 12370290
LTP
1.00
 - eIF_4EBP
0.83
 - medium
T 45 STTPGGTLFSTTPGGTRIIYD - 18220336
HTP
1.00
 - eIF_4EBP
0.65
 - medium
T 45 STTPGGTLFSTTPGGTRIIYD - 18669648
HTP
1.00
 - eIF_4EBP
0.65
 - medium
T 46 TTPGGTLFSTTPGGTRIIYDR mTOR 12370290
LTP
1.00
 - eIF_4EBP
0.62
 - medium
S 65 DRKFLMECRNSPVTKTPPRDL mTOR 12912989
LTP
1.00
 - eIF_4EBP
0.67
 - medium
S 65 DRKFLMECRNSPVTKTPPRDL - 17081983
HTP
1.00
 - eIF_4EBP
0.67
 - medium
S 65 DRKFLMECRNSPVTKTPPRDL - 17287340
HTP
1.00
 - eIF_4EBP
0.67
 - medium
T 70 MECRNSPVTKTPPRDLPTIPG mTOR 12370290
LTP
1.00
 - eIF_4EBP
0.80
 - medium
T 70 MECRNSPVTKTPPRDLPTIPG mTOR 12912989
LTP
1.00
 - eIF_4EBP
0.80
 - medium
T 70 MECRNSPVTKTPPRDLPTIPG - 17081983
HTP
1.00
 - eIF_4EBP
0.80
 - medium
T 70 MECRNSPVTKTPPRDLPTIPG - 17287340
HTP
1.00
 - eIF_4EBP
0.80
 - medium
S 83 RDLPTIPGVTSPSSDEPPMEA mTOR 9405468
LTP
0.20
 - eIF_4EBP
0.93
 - medium
S 85 LPTIPGVTSPSSDEPPMEASQ - 18669648
HTP
0.13
 - eIF_4EBP
0.92
 - medium
S 94 PSSDEPPMEASQSHLRNSPED - 17287340
HTP
0.09
 - eIF_4EBP
0.95
 - medium
S 101 MEASQSHLRNSPEDKRAGGEE mTOR 12912989
LTP
0.17
 - eIF_4EBP
0.92
 - medium
S 101 MEASQSHLRNSPEDKRAGGEE - 17287340
HTP
0.17
 - eIF_4EBP
0.92
 - medium
S 112 PEDKRAGGEESQFEMDI     ATM 11146653
LTP
0.03
 MOD_PIKK_1
 - eIF_4EBP
0.84
 - medium
S 112 PEDKRAGGEESQFEMDI     - 17525332
HTP
0.03
 MOD_PIKK_1
 - eIF_4EBP
0.84
 - medium

Substrate: eIF4E-binding protein 1 (Eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I))
Seq-ID: Q60876 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13782   FRAP_HUMAN
MINT-14953   KS6B1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
eukaryotic initiation factor 4E binding,
translation repressor activity		 cytoplasm insulin receptor signaling pathway,
negative regulation of translational initiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 36 VQLPPGDYSTTPGGTLFSTTP - 17141160
LTP
1.00
 - eIF_4EBP
0.82
 - medium
T 45 TTPGGTLFSTTPGGTRIIYDR - 17141160
LTP
1.00
 - eIF_4EBP
0.61
 - medium
S 64 DRKFLMECRNSPVAKTPPKDL - 17141160
LTP
1.00
 - eIF_4EBP
0.62
 - medium

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